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KMID : 0191120090240040760
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Journal of Korean Medical Science
2009 Volume.24 No. 4 p.760 ~ p.762
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Sinus Histiocytosis with Massive Lymphadenopathy: A Case Report with Pleural Effusion and Cervical Lymphadenopathy
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Ju Jin-Yung
Kwon Yong-Soo
Jo Kae-Jung
Chae Dong-Ryeol
Lim Jung-Hwan
Ban Hee-Jung
Chi Su-Young
Oh In-Jae
Kim Ku-Sik
Kim Yu-Il
Kim Young-Chul
Lim Sung-Chul
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Abstract
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Sinus histiocytosis with massive lymphadenopathy (SHML) is a rare disorder characterized by a nonneoplastic proliferation of distinctive histiocyte cells within lymph node sinuses and lymphatics in extranodal sites. SHML occurs worldwide and is primarily a disease of childhood and early adulthood. A 26-yr-old man presented with painless palpable lymph node in cervical area. Radiographic studies revealed pleural effusion with lymphadenopathy and calcification in mediastinum. The cervical lymph node biopsy showed dilated sinuses filled with histiocytes with clear cytoplasm. The cells stained positive with CD68 and S-100. These cytologic and immunohistochemical findings were considered consistent with the diagnosis of SHML.
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KEYWORD
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Histiocytosis, Sinus, Massive Lymphadenopathy, Rosai-Dorfman Disease
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